Research Funded

Targeting EWS-FLI1 Ewing Sarcoma through a rationale targeted therapy combination

Anthony Faber, PhD, Virginia Commonwealth University
Recipient of the: $50,000 Sarcoma Foundation of America Research Award

Abstract: The use of ALK inhibitors in ALK mutant familial and sporadic neuroblastoma has finally ushered in the era of targeted therapies in pediatric cancers, whereas in adult cancers, targeted therapies have been revolutionizing ... Read More

Epigenomic characterization of paired primary and metastatic osteosarcoma tumors to define novel therapeutic targets

Peter Scacheri, PhD, Case Western Reserve University – School of Medicine
Recipient of the: $50,000 STL Cure Sarcoma Research Award

Abstract: Distant metastases cause more than 90% of cancer-related mortality. Children suffering from osteosarcoma, where the typical route of spread is from bone to lung, are no exception. Unfortunately, 40% of these pediatric pati... Read More

A Novel Genetically Engineered Mouse Model for Angiosarcoma: Molecular Characterization and Comparison to Human Angiosarcoma to Develop Targeted Therapy

Lionel Mu-Lo Chow, MD, PhD, Cincinnati Children’s Hospital Medical Center
Recipient of the: $50,000 Pittsburgh Cure Sarcoma Co-Founder Bill Suit Research Award

Abstract: Angiosaroma is a rare and aggressive sarcoma of childhood and adults with a very poor overall survival of 25% at 5 years. No effective systemic therapy has been described for this disease. Little research has been done on ... Read More

Outbred Canine Model of Adjuvant Immunotherapy for Angiosarcoma

William Karl Decker, PhD, Baylor College of Medicine
Recipient of the: $50,000 Pittsburgh Cure Sarcoma Co-Founder Carl Firetto Memorial Research Award

Abstract: Cutaneous angiosarcoma is a deadly neoplasm of the dermal vascular endothelium that comprises roughly 1% of all soft tissue sarcomas. It is typically locally advanced at presentation, rendering surgical cure difficult and ... Read More

Modeling Epithelioid Sarcomagenesis in the Mouse

Jared Barrott, PhD, University of Utah
Recipient of the: $50,000 Jeffrey Thornton Memorial Research Award

Abstract: Epithelioid sarcoma (ES) is one of the deadliest subtypes of soft-tissue sarcoma. Despite its benign presentation it often metastasizes to the lymph nodes and lungs and is essentially always recalcitrant to standard chemot... Read More

Next Generation CRISPR Phenotypic Screens for Identification of Novel Therapeutic Targets in Rhabdomyosarcoma

Eleanor Chen, MD, PhD, University of Washington
Recipient of the: $50,000 Dr. Richard and Valerie Aronsohn Memorial Research Award

Abstract: Rhabdomyosarcoma is the most common pediatric soft tissue sarcoma. Survival rate remains poor for patients with relapsed or metastatic disease. There remains an urgent need for novel therapeutic targets. Our previous work ... Read More

The Next Generation of Antigen-Specific T cells for Sarcoma Therapies for Sarcoma

Seth Pollack, MD, Fred Hutchinson Cancer Research Center
Recipient of the: $50,000 Sarcoma Foundation of America Research Award

Abstract: Outcomes remain poor for patients with metastatic Synovial Sarcoma (SS) and Myxoid/ round cell liposarcoma (MRCL). Immunotherapeutic approaches may be well suited to SS and MRCL because both of these sarcoma subtypes chara... Read More

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