Chromosomal translocations creating novel fusion molecules occur frequently in sarcomas. These not only contribute to oncogenesis, but also serve as unique molecular tags distinguishing cancerous from non-cancerous cells. The rationale for this proposal is that these unique mRNA tags can be used to selectively target cells for death using cutting-edge programmable gene editing technologies. Reprogrammable ADAR Sensors (RADARS), is a newly developed system that recognizes a specific RNA transcript, and if present in the cell, activates the expression of a payload protein. The system works by expressing a “sensor” mRNA that includes a translational start site, a short initial open…  Read More »