Development of Novel RNA Sensor-Based Treatment for Ewing’s Sarcoma

Chromosomal translocations creating novel fusion molecules occur frequently in sarcomas. These not only contribute to oncogenesis, but also serve as unique molecular tags distinguishing cancerous from non-cancerous cells. The rationale for this proposal is that these unique mRNA tags can be used to selectively target cells for death using cutting-edge programmable gene editing technologies. Reprogrammable ADAR Sensors (RADARS), is a newly developed system that recognizes a specific RNA transcript, and if present in the cell, activates the expression of a payload protein. The system works by expressing a “sensor” mRNA that includes a translational start site, a short initial open…  Read More »