Archive for the ‘Meet the Researcher’ Category
William K. Decker, PhD, Associate Professor, Baylor College of Medicine 2016 Pittsburgh Cure Sarcoma Co-Founder Carl Firetto Memorial Research Award: “Outbred Canine Model of Adjuvant Immunotherapy for Angiosarcoma” PLEASE DESCRIBE THE FOCUS OF THE RESEARCH PERFORMED IN YOUR LAB. We study the basic immunobiology of dendritic cells and the manner by which this critical cell subtype orchestrates TH polarization. TH polarization sounds complicated – and it is – but can be explained relatively easily. The adaptive immune system makes two main types of fundamentally different immune responses. One of these responses, termed TH2, is aimed at eliminating pathogens that… Read More »
Andrew Koff, PhD, Member and Professor, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center 2014 Heidi Connery Memorial Research Grant: “Proteomic and genomic approaches to understanding intrinsic and acquired resistance to CDK4 inhibition therapy in well differentiated/dedifferentiated liposarcoma” PLEASE DESCRIBE THE FOCUS OF THE RESEARCH PERFORMED IN YOUR LAB. The laboratory of cell cycle regulation at Memorial Sloan Kettering Cancer Center is interested in identifying the genes and proteins that regulate the transition of cells from quiescence, a reversible type of proliferative exit, to senescence, a more stable irreversible type of proliferative exit. Proliferation associated with a deregulated cell cycle… Read More »
Brian A. Van Tine, MD, PhD Assistant Professor of Medicine, Sarcoma Program Director, Washington University in St. Louis 2013 Sarcoma Foundation of America Research Grant Recipient: “A Metabolomic Approach to Targeting ASS1 Deficient Sarcomas” 2014 Sarcoma Foundation of America Research Grant Recipient: “Targeting the Pentose Phosphate Pathway for the Treatment of Synovial Sarcoma” 2017 Sarcoma Foundation of America Research Grant Recipient: “Targeting the alterations of Lipid Metabolism in ASS1 Deficient Sarcomas to Induce Synthetic Lethality” PLEASE DESCRIBE THE FOCUS OF THE RESEARCH PERFORMED IN YOUR LAB. I am an Assistant Professor of Medicine in the Department of Medicine at Washington… Read More »
Kurt Richard Weiss, MD Assistant Professor, Department of Orthopaedic Surgery, Division of Musculoskeletal Oncology, Director of the Cancer Stem Cell Laboratory, University of Pittsburgh Medical Center 2013 Sarcoma Foundation of America Research Grant Recipient: “Investigation Of Novel Anti-Metastatic Therapy For Osteosarcoma” PLEASE DESCRIBE THE FOCUS OF THE RESEARCH PERFORMED IN YOUR LAB. Although there are dozens of distinct histologic subtypes of sarcoma, they all share one deadly characteristic: the propensity to metastasize (spread) to the lungs. Indeed, pulmonary metastases are the main cause of mortality in sarcoma patients of all ages. Although the… Read More »