Blocking SYT-SSX Activities Using an Inhibitory Peptide

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Yuechueng Liu, PhD,  University of Oklahoma Health Sciences Center
Recipient of the: $25,000 Paul M. Rumely Memorial Research Award

The long-term goal of this research is to understand the role of syt-ssx gene product in synovial sarcoma pathogenesis, and to develop novel and effective treatment for the disease. The cause of synovial sarcoma is unknown. However, a characteristic fusion of two genes, syt and ssx, has been identified. We have recently discovered a peptide that blocks SYT function in vitro. Based on the finding, I propose to further determine if this peptide is able to target SYT-SSX and block its activities in vivo. This may eventually lead to the discovery of novel treatment for synovial sarcoma.