Our recent microarray collaborative studies demonstrate that tenosynovial giant cell tumor and aggressive soft tissue leiomyosarcomas express macrophage colony stimulating factor, which appears to represent a key factor driving these neoplasms. New drugs inhibit this target, but appropriate models which include a tumor-host macrophage interaction are lacking. We recently found that primary tumor renal subcapsular xenografts can attract host macrophages and seek to establish if this model can serve as a preclinical assay for an anti-CSF1 targeted treatment strategy in these diseases.
Paul W. Clarkson, MBChB, British Columbia Cancer Agency
Recipient of the: $25,000 Brian J. Monaghan Memorial Research Award