CSF1 inhibitors in soft tissue tumors

Paul W. Clarkson, MBChB,  British Columbia Cancer Agency
Recipient of the: $25,000 Brian J. Monaghan Memorial Research Award

Our recent microarray collaborative studies demonstrate that tenosynovial giant cell tumor and aggressive soft tissue leiomyosarcomas express macrophage colony stimulating factor, which appears to represent a key factor driving these neoplasms. New drugs inhibit this target, but appropriate models which include a tumor-host macrophage interaction are lacking. We recently found that primary tumor renal subcapsular xenografts can attract host macrophages and seek to establish if this model can serve as a preclinical assay for an anti-CSF1 targeted treatment strategy in these diseases.