Research Funded

Enhanced NK cell Immunotherapy for Treatment of Chemotherapy Refractory Sarcoma

Daniel Vallera, PhD, University of Minnesota – Twin Cities
Recipient of the: $50,000 Dr. Richard and Valerie Aronsohn Memorial Research Award

Abstract: Radiation therapy is a crucial treatment modality required to control soft tissue and advanced bone sarcomas. Despite technological advancements used to treat radioresistant sarcomas, local recurrence and metastasis contin... Read More

MCL-1 inhibition unmasks BCL-2 addiction in synovial sarcoma

Anthony Faber, PhD, Virginia Commonwealth University
Recipient of the: $50,000 Zach Cohen Memorial Research Award

Abstract: Metastatic Synovial Sarcoma (mSS) is frequently diagnosed in teenagers and young adults and continues to be treated with polychemotherapy with variable success. The SS18-SSX gene fusion is pathogenomic for the disease, and... Read More

Identification of novel drug targets and predictors of clinical outcomes in desmoplastic small round cell tumors using next-generation sequencing

Madelyn Espinosa-Cotton, PhD, Memorial Sloan-Kettering Cancer Center
Recipient of the: $50,000 Zach Cohen Memorial Research Award

Abstract: Desmoplastic small round cell tumor (DSRCT) is a rare, highly-aggressive soft-tissue sarcoma with an overall five-year survival rate of less than 30%. Next generation sequencing (NGS) has given cancer researchers unprecede... Read More

Unraveling the tumor immune microenvironment of angiosarcomas

Yvonne Versleijen-Jonkers, PhD, Radboud University Nijmegen Medical Center
Recipient of the: $50,000 Catherine Malatesta Memorial Research Award

Abstract: Is immune checkpoint inhibition the solution for angiosarcoma patients? Genetic and immune profiles of angiosarcoma subtypes will lead to novel insights for the design of individualized immune checkpoint-based therapy for ... Read More

Identifying mechanisms of osteosarcoma chemoresistance that arise from the lung metastatic niche

Ryan Roberts, MD, PhD, The Research Institute at Nationwide Children’s Hospital
Recipient of the: $50,000 Pittsburgh Cure Sarcoma Research Award

Abstract: A therapy preventing the emergence of lung metastasis in adolescents with osteosarcoma could save more than 70% of the lives currently lost to this disease. This would represent the most significant improvement in outcome ... Read More

Imaging response to CD47 mAb immunotherapy in pediatric patients with osteosarcoma

Heike Daldrup-Link, MD, PhD, Stanford University
Recipient of the: $50,000 Race to Cure Sarcoma Research Award

Abstract: Children with metastatic bone cancer have a poor prognosis, with an overall survival rate of less than 30%. Stanford investigators developed a new drug, monoclonal antibodies against the cancer cell marker CD47 (CD mAb), w... Read More

The Role of Pseudogenes as Regulators of the IGF2BP2/IGF1R/RAS Axis in Rhabdomyosarcoma: Functional Characterization in Myogenesis and Implications for Anticancer Therapy

Sonia Guil, PhD, Josep Carreras Leukaemia Research Institute
Recipient of the: $50,000 Race to Cure Sarcoma Research Award

Abstract: In the study of cellular mechanisms that are out of control in cancer, noncoding RNAs(ncRNAs) are becoming increasingly important: these are transcripts that do not code for proteins, but which frequently play regulatory r... Read More

Phase I-II trial of sunitinib plus nivolumab after standard treatment in advanced soft tissue and bone sarcomas

Javier Martin-Broto, MD, PhD, Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla
Recipient of the: $50,000 Race to Cure Sarcoma Research Award

Abstract: Sarcomas are rare, life-threatening, malignant tumors affecting soft, visceral, and bone tissues. Due to their high heterogeneity (more than 60 subtypes), many sarcomas lack effective therapies. Incidence is 50-60 new case... Read More

Immunomodulation of Ewing sarcoma to enhance allogenic NK cell therapy

Masanori Hayashi, MD, University of Colorado Denver
Recipient of the: $50,000 Sarcoma Foundation of America Research Award

Abstract: While the introduction of the combination of intensive chemotherapy and multi-modal While the use of chemotherapy, surgery and irradiation have improved outcomes in Ewing sarcoma (ES), such about 70% of patients are cure, ... Read More