Research Funded

Abstract: A therapy preventing the emergence of lung metastasis in adolescents with osteosarcoma could save more than 70% of the lives currently lost to this disease. This would represent the most significant improvement in outcome ... Read More

Abstract: Ewings sarcoma is a rare type of cancerous tumor that grows in bones or the soft tissue around the bones, such as cartilage or the nerves. It usually affects children and young adults between the ages of 10 to 19. Ewings s... Read More

Abstract: Liposarcomas are the most common histologies of soft tissue sarcomas. Although the most common subtypes of liposarcoma, well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS), often coexist, their... Read More

Abstract: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood characterized by the inability to exit the proliferative myoblast-like stage. RMS can be divided in two main histopathological subtypes: alveolar (... Read More

Abstract: Most soft tissue sarcomas (STS) remain incurable in the metastatic setting with traditional chemotherapy. Immune checkpoint inhibitors (ICIs), including antibodies to PD-1/PD-L1 and CTLA-4, act by reversing tumor-mediated ... Read More

Abstract: Children with metastatic bone cancer have a poor prognosis, with an overall survival rate of less than 30%. Stanford investigators developed a new drug, monoclonal antibodies against the cancer cell marker CD47 (CD mAb), w... Read More

Abstract: Long-read sequencing (LRS) technologies permit to continuously read individual DNA/RNA molecules over long stretches of DNA (>10kb), thus providing unparalleled information to resolve complex structural variants (SVs), ... Read More

Abstract: Liposarcomas (LPS) are classified in three principal subtypes: pleomorphic, myxoid/round cell and well-differentiated/de-differentiated (WD/DD); each of them with different clinical behavior, treatment sensitivity and unde... Read More

Abstract: In the study of cellular mechanisms that are out of control in cancer, noncoding RNAs(ncRNAs) are becoming increasingly important: these are transcripts that do not code for proteins, but which frequently play regulatory r... Read More

Abstract: Sarcomas are rare, life-threatening, malignant tumors affecting soft, visceral, and bone tissues. Due to their high heterogeneity (more than 60 subtypes), many sarcomas lack effective therapies. Incidence is 50-60 new case... Read More

Abstract: While the introduction of the combination of intensive chemotherapy and multi-modal While the use of chemotherapy, surgery and irradiation have improved outcomes in Ewing sarcoma (ES), such about 70% of patients are cure, ... Read More

Abstract: Leiomyosarcomas (LMS) are aggressive tumors of the smooth muscle with no available effective treatments and a 2-year survival rate of 20%. They represent up to 25% of all soft tissue sarcomas (STS) and are the most common ... Read More

Abstract: We are trying to improve immunotherapy for patients with synovial sarcoma (SS) and myxoid/round cell liposar-coma (MRCL); these cancers "should" be ideal candidates for immunotherapy as they have uniquely high and consiste... Read More

Abstract: The trajectory of cancer progression is shaped by evolutionary processes on a variety of time scales. Evolutionary selection forces drive populations towards more fit phenotypes over generations, yet individual cancer cell... Read More

Abstract: MPNST (malignant peripheral nerve sheath tumors) are highly aggressive soft tissue sarcomas of Schwann cell (SC) origin, representing a major cause of mortality in neurofibromatosis (NF) patients, which affects 1 in 3500 i... Read More

Abstract: Soft tissue sarcomas are a rare entity of very heterogeneous tumors, both epidemiological, histological and molecular. Clinically, sarcomas can occur at any age of life and develop throughout the body. They are associated ... Read More

Abstract: NG2/CSPG4 transmembrane proteoglycan (PG) is a multivalent cell surface macromolecule whose impact on tumour growth and dissemination has been extensively documented in a variety of tumours and animal models. The PG is abu... Read More

Abstract: Leiomyosarcomas (LMS) are rare highly malignant tumors of mesenchymal origin. Standard treatment is surgery and adjuvant radiotherapy. Unfortunately, local recurrence and metastasis develop in approximately 40% of cases, w... Read More

Abstract: Undifferentiated Pleiomorphic Sarcoma (UPS) is one of the most aggressive subtypes of soft tissue sarcoma. Besides earlier detection by novel imaging techniques, little has been found to improve the overall survival of the... Read More

Abstract: Osteosarcoma is the most common primary bone cancer affecting children and adolescences worldwide. However, since the introduction of chemotherapy, the overall survival rate has been plateaued for more than 30 years, remai... Read More

Abstract: The discovery of oncogenic neomorphic mutations in the genes coding for the metabolic enzymes Isocitrate Dehydrogenase (IDH) 1 & 2 has driven a search to uncover their oncogenic mechanism and to target them therapeutic... Read More

Abstract: Embryonal rhabdomyosarcoma (ERMS) is one of the most common and devastating pediatric soft tissue sarcomas. While localized disease can be controlled with multi-modal therapies, there remains no effective therapy for patie... Read More

Abstract: The survival rates of metastatic patients with Ewing sarcoma (ES) are still a disappointing 20-40%, motivating the search for effective novel therapeutic targets. ES is particularly sensitive to treatment with DNA damage i... Read More

Abstract: Pleomorphic rhabdomyosarcoma (PRMS) is a rare soft tissue tumor of the skeletal muscle that occurs predominantly in middle-aged adults. No standard systemic therapy options are available, and surgical resection is the most... Read More

Abstract: Radiation-associated cutaneous angiosarcoma (RAA) is a highly aggressive malignancy that arises in breast cancer patients approximately 5-10 years following treatment with adjuvant radiotherapy (RT). The median survival of... Read More