Research Funded

Abstract: Vascular sarcomas (e.g. angiosarcomas, hemangiosarcomas, and hemangioendotheliomas) represent a therapeutic challenge since new treatment approaches have not occurred in several decades. We and others recently published re... Read More

Abstract: A distinguishing feature of cancer cells is their ability to undergo aerobic glycolysis (known as the Warburg effect), allowing them to thrive in a variety of microenvironments. Monocarboxylate transporters (MCTs) are key ... Read More

Abstract: Soft tissue sarcomas represent a rare, aggressive, and complex group of malignancies. Patients with large or high-grade soft tissue sarcomas often receive radiation therapy in combination with surgery. Some sarcomas may oc... Read More

Abstract: Chondrosarcomas are the most common primary sarcoma of the bone in patients older than age 50. Although the majority of chondrosarcomas is of low or intermediate grade, high-grade chondrosarcomas are very aggressive tumors... Read More

Abstract: Current approaches to adoptive cell therapy (ACT) for metastatic synovial sarcomas are limited by the difficulty of obtaining sufficient numbers of less-differentiated T cells and existence of immune suppressive pathways. ... Read More

Abstract: A tumor must evade destruction by the host’s immune system in order to grow. Immunotherapy works by enhancing or restoring the anti-tumor effects of the immune system. Checkpoint blockade has demonstrated efficacy in mul... Read More

Abstract: Chemotherapy response is the primary determinant of long term survival for patients with osteosarcoma (OS), where patients who are resistant to chemotherapy are considered incurable. The ultimate goal of this study is to i... Read More

Abstract: The overall survival for recurrent and metastatic Ewing sarcoma (EWS) is dismal (15% and 10-30%, respectively). We previously showed that EWS has a defect in double-strand DNA (dsDNA) repair, and that the addition of Poly ... Read More

Abstract: The most common defect in sarcoma is loss of expression of argininosuccinate synthetase 1 (ASS1), which occurs in approximately 90% of sarcomas. This defect primes sarcomas for treatment by the arginine starvation inducing... Read More

Abstract: Despite multiple advances in cancer therapy, osteosarcoma survival remains heavily dependent upon the existence of metastatic disease at the time of diagnosis. Patients with non-metastatic osteosarcoma have a survival rate... Read More

Abstract: The use of ALK inhibitors in ALK mutant familial and sporadic neuroblastoma has finally ushered in the era of targeted therapies in pediatric cancers, whereas in adult cancers, targeted therapies have been revolutionizing ... Read More

Abstract: Distant metastases cause more than 90% of cancer-related mortality. Children suffering from osteosarcoma, where the typical route of spread is from bone to lung, are no exception. Unfortunately, 40% of these pediatric pati... Read More

Abstract: Angiosaroma is a rare and aggressive sarcoma of childhood and adults with a very poor overall survival of 25% at 5 years. No effective systemic therapy has been described for this disease. Little research has been done on ... Read More

Abstract: Cutaneous angiosarcoma is a deadly neoplasm of the dermal vascular endothelium that comprises roughly 1% of all soft tissue sarcomas. It is typically locally advanced at presentation, rendering surgical cure difficult and ... Read More

Abstract: Epithelioid sarcoma (ES) is one of the deadliest subtypes of soft-tissue sarcoma. Despite its benign presentation it often metastasizes to the lymph nodes and lungs and is essentially always recalcitrant to standard chemot... Read More

Abstract: One of the major challenges associated with clinical and translational research in patients with bone and soft tissue tumors has been the relative rarity of bone and soft-tissue tumors and a dearth of well-annotated clinic... Read More

Abstract: Rhabdomyosarcoma is the most common pediatric soft tissue sarcoma. Survival rate remains poor for patients with relapsed or metastatic disease. There remains an urgent need for novel therapeutic targets. Our previous work ... Read More

Abstract: Targeting YAP/HIPPO pathway in embryonal rhabdomyosarcoma Abstract: ... Read More

Abstract: Outcomes remain poor for patients with metastatic Synovial Sarcoma (SS) and Myxoid/ round cell liposarcoma (MRCL). Immunotherapeutic approaches may be well suited to SS and MRCL because both of these sarcoma subtypes chara... Read More

Abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract affecting approximately 5,000 individuals in the US each year. Up to 90% of GISTs arise from the interstitial cell... Read More

Abstract: Tumor immunotherapy with chimeric antigen receptor (CAR)-modified T cells has shown substantial efficacy in early phase clinical trials. Targeting a single tumor associated antigen (TAA) could however result in creation of... Read More

Abstract: The long-term goal of this project is to develop an effective immunotherapy for patients with metastatic and/or recurrent OS osteosarcoma (OS), whose prognosis remains poor despite aggressive multimodality therapy. Immunot... Read More

Abstract:   Rationale: Ewing sarcoma, the second most common pediatric bone cancer, is a highly lethal malignancy. Despite multimodal therapy, recurrence and mortality remain high for metastatic cases. It has been proposed th... Read More

Abstract: Malignant vascular tumors are a type of sarcoma that originates from transformed endothelial cells. While the disease is rare (2% of all sarcomas), these tumors are highly invasive and display low survival (50% lethality /... Read More

Abstract: Angiosarcomas are highly lethal tumors composed primarily of aberrant lymphatic and/or vascular endothelial cells. These tumors most commonly occur as facial dermatologic lesions and account for over 50% of radiation-induc... Read More