Research Funded

Abstract: Hypothesis: Targeting the pRb pathway with a focus on immunomodulatory effects offers a novel method to improve treatment outcomes in children with metastatic osteosarcoma. Rationale: Our preliminary evidence showing ant... Read More

Abstract: Synovial Sarcoma is a soft tissue sarcoma subtype with poor outcomes in the advanced setting. Although it is immunologically “cold,” it generally expresses the highly immunogenic protein NY-ESO-1. Although NY-ESO-1 has... Read More

Abstract: Loss of function mutations of STAG2 occur in 10-15% of Ewing sarcoma (ES) patients. This is clinically significant, as loss of STAG2 is associated with poor clinical outcomes. STAG2 encodes a protein that is central to the... Read More

Abstract: Despite significant efforts within oncology, effective therapies for alveolar rhabdomyosarcoma (ARMS) remain unrealized. Patients with ARMS are treated with intensive multimodal therapy, but outcomes still remain unaccepta... Read More

Abstract: The vast majority of patients with soft tissue sarcoma present with localized disease, yet nearly half of these patients develop incurable distant metastases. Chemotherapy has been marginally effective in reducing the rate... Read More

Abstract: Ewing Sarcomas (ES) are biologically aggressive tumors of bone and soft tissues, characterized by in frame chromosomal translocation leading to the expression of the EWS-FLI1 oncogene. They affect mainly children and adole... Read More

Abstract: Targeting chromatin-remodeling enzymes holds great promise for treating soft tissue sarcomas (STS) since 1) the key oncogenic drivers in many sarcomas are translocation-derived chimeric transcription factors whose activiti... Read More

Abstract: Sarcomas are uncommon and poorly understood malignancies of mesenchymal tissues. Their histologic diversity and diagnostic complexity bring tremendous challenge to optimal clinical management. The lack of understanding of ... Read More

Abstract: The Plexin-Semaphorin pathway is previously unexplored as a target in sarcomas but may play a central role in the progression of the soft tissue sarcoma, rhabdomyosarcoma. Rhabdomyosarcoma is the most common soft tissue sa... Read More

Abstract: Sarcomas are a heterogeneous group of malignancies with a 50% mortality at 5 years across all subtypes and stages. The 5 year survival for patients with metastatic disease is only 15%.The results from chemotherapeutic agen... Read More

Abstract: Sarcomas are a group of over 100 types of tumors of mesenchymal origin that can be divided into soft tissue sarcomas (STS) and bone sarcomas. The most common agents used to treat all sarcomas are anthracyclines, such as do... Read More

Abstract: Metastatic osteosarcoma has a poor prognosis, yet systemic standard of care therapies renders patients with great morbidity and life-long disabilities. Thus, there is an urgency to discover less toxic and more effective th... Read More

Abstract: Vascular sarcomas (e.g. angiosarcomas, hemangiosarcomas, and hemangioendotheliomas) represent a therapeutic challenge since new treatment approaches have not occurred in several decades. We and others recently published re... Read More

Abstract: A distinguishing feature of cancer cells is their ability to undergo aerobic glycolysis (known as the Warburg effect), allowing them to thrive in a variety of microenvironments. Monocarboxylate transporters (MCTs) are key ... Read More

Abstract: Soft tissue sarcomas represent a rare, aggressive, and complex group of malignancies. Patients with large or high-grade soft tissue sarcomas often receive radiation therapy in combination with surgery. Some sarcomas may oc... Read More

Abstract: Chondrosarcomas are the most common primary sarcoma of the bone in patients older than age 50. Although the majority of chondrosarcomas is of low or intermediate grade, high-grade chondrosarcomas are very aggressive tumors... Read More

Abstract: Current approaches to adoptive cell therapy (ACT) for metastatic synovial sarcomas are limited by the difficulty of obtaining sufficient numbers of less-differentiated T cells and existence of immune suppressive pathways. ... Read More

Abstract: A tumor must evade destruction by the host’s immune system in order to grow. Immunotherapy works by enhancing or restoring the anti-tumor effects of the immune system. Checkpoint blockade has demonstrated efficacy in mul... Read More

Abstract: Chemotherapy response is the primary determinant of long term survival for patients with osteosarcoma (OS), where patients who are resistant to chemotherapy are considered incurable. The ultimate goal of this study is to i... Read More

Abstract: The overall survival for recurrent and metastatic Ewing sarcoma (EWS) is dismal (15% and 10-30%, respectively). We previously showed that EWS has a defect in double-strand DNA (dsDNA) repair, and that the addition of Poly ... Read More

Abstract: The most common defect in sarcoma is loss of expression of argininosuccinate synthetase 1 (ASS1), which occurs in approximately 90% of sarcomas. This defect primes sarcomas for treatment by the arginine starvation inducing... Read More

Abstract: Despite multiple advances in cancer therapy, osteosarcoma survival remains heavily dependent upon the existence of metastatic disease at the time of diagnosis. Patients with non-metastatic osteosarcoma have a survival rate... Read More

Abstract: The use of ALK inhibitors in ALK mutant familial and sporadic neuroblastoma has finally ushered in the era of targeted therapies in pediatric cancers, whereas in adult cancers, targeted therapies have been revolutionizing ... Read More

Abstract: Distant metastases cause more than 90% of cancer-related mortality. Children suffering from osteosarcoma, where the typical route of spread is from bone to lung, are no exception. Unfortunately, 40% of these pediatric pati... Read More

Abstract: Angiosaroma is a rare and aggressive sarcoma of childhood and adults with a very poor overall survival of 25% at 5 years. No effective systemic therapy has been described for this disease. Little research has been done on ... Read More