Identification of aberrantly methylated genes in Ewing sarcoma

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Scott Borinstein, MD, PhD,  Fred Hutchinson Cancer Research Center
Recipient of the: $25,000 ARIAD and Merck Research Award

DNA methylation is part of a complex mechanism that regulates genes.  The goal of this proposal is to identify genes that are “turned off” by DNA methylation and contribute to Ewing Sarcoma tumor formation.  We will determine if the methylation pattern of these genes is associated with tumor location, tumor spread, and how the neoplasm responded to treatment.  We hope that this study will lead us to better understanding of the cause of ES and will lead to the development of better diagnostic and therapeutic modalities for these patients.