Research Funded

Abstract: Leiomyosarcomas (LMS) are aggressive tumors of the smooth muscle with no available effective treatments and a 2-year survival rate of 20%. They represent up to 25% of all soft tissue sarcomas (STS) and are the most common ... Read More

Abstract: We are trying to improve immunotherapy for patients with synovial sarcoma (SS) and myxoid/round cell liposar-coma (MRCL); these cancers "should" be ideal candidates for immunotherapy as they have uniquely high and consiste... Read More

Abstract: The trajectory of cancer progression is shaped by evolutionary processes on a variety of time scales. Evolutionary selection forces drive populations towards more fit phenotypes over generations, yet individual cancer cell... Read More

Abstract: MPNST (malignant peripheral nerve sheath tumors) are highly aggressive soft tissue sarcomas of Schwann cell (SC) origin, representing a major cause of mortality in neurofibromatosis (NF) patients, which affects 1 in 3500 i... Read More

Abstract: Soft tissue sarcomas are a rare entity of very heterogeneous tumors, both epidemiological, histological and molecular. Clinically, sarcomas can occur at any age of life and develop throughout the body. They are associated ... Read More

Abstract: NG2/CSPG4 transmembrane proteoglycan (PG) is a multivalent cell surface macromolecule whose impact on tumour growth and dissemination has been extensively documented in a variety of tumours and animal models. The PG is abu... Read More

Abstract: Leiomyosarcomas (LMS) are rare highly malignant tumors of mesenchymal origin. Standard treatment is surgery and adjuvant radiotherapy. Unfortunately, local recurrence and metastasis develop in approximately 40% of cases, w... Read More

Abstract: Undifferentiated Pleiomorphic Sarcoma (UPS) is one of the most aggressive subtypes of soft tissue sarcoma. Besides earlier detection by novel imaging techniques, little has been found to improve the overall survival of the... Read More

Abstract: Osteosarcoma is the most common primary bone cancer affecting children and adolescences worldwide. However, since the introduction of chemotherapy, the overall survival rate has been plateaued for more than 30 years, remai... Read More

Abstract: The discovery of oncogenic neomorphic mutations in the genes coding for the metabolic enzymes Isocitrate Dehydrogenase (IDH) 1 & 2 has driven a search to uncover their oncogenic mechanism and to target them therapeutic... Read More