Research Funded

Abstract: Cancer immunotherapies have revolutionized how some tumor types are treated. However, evidence for their benefit in sarcoma patients remains limited with only small subsets of patients responding to treatments. Impressive ... Read More

Abstract: Substantial progress has been made in the treatment of paediatric patients affected by oncological malignancies over the past decades. However, children with high-risk, metastatic or relapsed disease continue to have poor ... Read More

Abstract: Leiomyosarcoma (LMS) is one of the most common soft tissue sarcomas, representing up to 20% of all of them. Many LMS originate directly from smooth muscle cells or from their precursor showing a predilection for uterus, la... Read More

Abstract: Kaposi sarcoma (KS) is a highly vascularized tumor of the skin and viscera that is driven by the oncogenic Kaposi Sarcoma Herpesvirus (KSHV). Skin KS can cause painful edema while visceral KS of the lungs or gastrointestin... Read More

Abstract: Approximately 20% of sarcomas are driven by oncogenic translocations, which commonly involve transcriptional regulators. Alveolar soft part sarcoma (ASPS) is a sarcoma most commonly diagnosed in young adults and characteri... Read More

Abstract: CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic cancer that mainly affects children and young adults, and the prognosis for the affected is very poor with an overall survival of only 14 months. Currently, with... Read More

Abstract: Rhabdomyosarcoma (RMS), the most common STS in pediatric, adolescent and young adult patients. RMS is a devastating malignancy; outcomes for patients with high-risk disease are dismal and unlike many pediatric cancers, hav... Read More

Abstract: Over the past decade, immunotherapy has revolutionized cancer care across many cancer types by harnessing the body’s immune system to fight tumor cells. However, response to current immunotherapies in undifferentiated pl... Read More

Abstract: The body’s immune system has a tremendous ability to fight disease including cancer, with strategies to reinvigorate immune responses against cancer winning the Nobel Prize in 2018 – and multiple immunotherapy drugs ap... Read More

Abstract: Desmoplastic small round cell tumor (DSRCT) is a rare, usually incurable, pediatric sarcoma that afflicts mostly young males. While the EWS-WT1 fusion protein (FP) is a hallmark of DSRCT, equally pervasive is the dense fib... Read More

Abstract: Osteosarcoma is pediatric cancer with peak incidence during the adolescent growth spurt. It is the most common bone cancer and is mostly found in the long bones such as the legs. Since the introduction of chemotherapy in t... Read More

Abstract: Soft tissue sarcomas are a collection of rare tumor types originated from soft tissues such as muscle, tendon, fat, etc. Among them, undifferentiated sarcomas represent a group of the most common types of soft tissue sarco... Read More

Abstract: Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents, comprising 3-5% of all pediatric cancers. Overall survival rates for high-grade OS in the pediatric population are only ~60% and have rem... Read More

Abstract: Mesenchymal chondrosarcoma is a high-grade, malignant, primitive mesenchymal tumor. It accounts for 2%~4% of all chondrosarcomas and mainly affects adolescents and young adults. Mesenchymal chondrosarcoma has a strong tren... Read More

Abstract: Background: Sarcoma is a heterogeneous group of malignant tumors that consist of distinct histological and molecular subtypes, each with unique clinical, therapeutic and prognostic features. Despite immunotherapy showing p... Read More

Abstract: Ewing sarcoma (EwS) is the second most common childhood bone malignancy, primarily affecting children, adolescents and young adults. The mutational landscape of the EwS genome is relatively quiet and is primarily defined b... Read More

Abstract: Despite the multimodal treatment approach with aggressive chemotherapy and surgery, 30-35% of Osteosarcoma (OS) patients develop lung metastases and the survival rate for these patients is <20%. Novel therapeutic strate... Read More

Abstract: Alveolar rhabdomyosarcomas (aRMS) are highly aggressive pediatric sarcomas, associated with the skeletal muscle lineage. These tumors are believed to originate from differentiation defects during myogenesis, the process of... Read More

Abstract: A significant impediment to the development of curative cancer therapy is the dose-limiting toxicity of therapeutic anticancer treatments. We have developed tumor-targeted bacterially delivered anticancer immunotherapy to ... Read More

Abstract: Leiomyosarcoma (LMS) is one of the most common subtypes of soft tissue sarcoma. Classically, LMSs are characterized by an aggressive clinical course, a heterogeneous genetic profile and a very poor response to cytotoxic ch... Read More

Abstract: In children, adolescents, and young adults (AYA), osteosarcoma (OS) is the most common type of bone cancer. Approximately 25-50% of OS patients have metastatic lesions at the time of diagnosis and no standard second-line t... Read More

Abstract: Perivascular Epithelioid Cell tumours (PEComas) are a group of ultra-rare mesenchymal tumours most commonly occurring in the 4th and 5th decade with a strong female predominance. Most PEComas have specific driver mutations... Read More

Abstract: Osteosarcoma is a cancer that starts in the bone, and affects mostly children, especially during puberty. Osteosarcoma has a ~33% higher incidence in African Americans (AA) (6.8 per million persons per year) than in whites... Read More