Synovial Sarcoma is an aggressive soft tissue tumor (SS) that afflicts young adults. Its high fatality rate warrants the design of more efficient curative approaches. SS is characterized by a unique translocation that creates the SYT-SSX fusion protein. SYT-SSX plays a central role in the development of SS. Here we present active Wnt/beta-catenin signaling as a downstream cascade of SYT-SSX and as an ideal candidate pathway for targeting in SS. We will generate murine models to assess the extent of Wnt/beta-catenin signaling contribution to SS formation and measure the effect of a specific pharmacological beta-catenin inhibitor on SS tumor growth.
Josiane Eid, M.D., Vanderbilt University Medical Center
Recipient of the: $25,000 research award